The cameras will be enforced following the successful installation last month between the M6 junction 31 and Glenluce Drive.
This is the sixth of eight routes across the county to go live, with the final routes on the A583 Preston New Road and A682 Gisburn Road expected to go live before the end of the year.
The Lancashire Road Safety Partnership (LRSP) gave the go ahead for the scheme last year and in January announced the chosen routes in a bid to reduce road casualties and collisions.
The Partnership decided to adopt the system using average speed cameras as motorist compliance has consistently improved on a variety of road types using the system in other parts of the UK.
The cameras will use number plate recognition technology to detect vehicles and calculate their average speed by measuring the time taken to travel between fixed points of a known distance apart. Average speed check signage will be used to inform drivers that they are entering an average speed control zone.
The introduction of the system is intended to positively influence driver behaviour and ensure that motorists comply with the set limits on roads, resulting in a safer environment for all road users.
There will be sanctions for anyone detected breaching the speed limits, where eligible they will be given the opportunity to attend a speed awareness course to learn about the dangers of speeding, accept a conditional offer of a fixed penalty (currently £100 and 3 penalty points) or for higher speeds the matter may be referred to court.